Targeted Protocols.
Target the Nerve. Control the Pain.®
Precision OrthoCryo® delivers cryoneurolysis protocols for the four most common orthopedic procedures — each backed by peer-reviewed clinical evidence and delivered by credentialed providers within your hospital.
How Cryoneurolysis
Works
Cryoneurolysis uses precisely controlled cold temperatures to temporarily interrupt the function of targeted sensory nerves. The iovera° system delivers a focused freeze to the nerve, causing a reversible Wallerian degeneration — blocking pain signals for 60–90 days while preserving motor function entirely.
Unlike opioids (systemic, addictive), nerve blocks (hours-long), or steroid injections (weeks, systemic effects), cryoneurolysis is targeted, drug-free, and provides lasting relief through the critical post-operative recovery window.
Precise delivery to specific sensory nerves. Motor function fully preserved.
No opioids, steroids, or local anesthetics. Zero systemic side effects.
Up to 90 days of relief — covering the entire post-operative recovery window.
Nerves regenerate naturally. No permanent damage. Full sensation returns.
Cryoneurolysis vs. Alternatives
How iovera° cryoneurolysis compares to standard pain management approaches
| Attribute | Opioids | Nerve Block | Steroid Injection | Cryoneurolysis |
|---|---|---|---|---|
| Duration of Relief | Hours–Days | Hours | Weeks | Up to 90 Days |
| Drug-Free | ✗ | ✗ | ✗ | ✓ |
| Motor Function Preserved | ✓ | ✗ | ✓ | ✓ |
| Systemic Side Effects | Significant | Minimal | Moderate | None |
| Addiction Risk | High | None | None | None |
| Reversible | N/A | Yes | Yes | Yes |
| Covers Recovery Window | Partial | ✗ | Partial | ✓ |
Knee Pain Relief
Before & After Your Knee Replacement
What to Expect
If you're preparing for a knee replacement — or recovering from one — iovera° cryotherapy can dramatically reduce your pain without opioids. A quick, in-office treatment uses gentle cold to calm the nerves around your knee, so you feel less pain before surgery and recover faster afterward.
- Total Knee Replacement
- Partial Knee Replacement
- Knee Revision Surgery
- Chronic Knee Pain (non-surgical)
You receive the iovera° treatment 1–3 days before your knee replacement. It takes about 30 minutes and you stay awake and comfortable the whole time.
Because your nerves are already calmed, you need less anesthesia and wake up more comfortably in recovery.
You'll experience significantly less pain in the hospital, which means you can start moving sooner and go home earlier.
Pain relief continues for up to 90 days — the most critical window for physical therapy and getting your strength back.
Hip Pain Relief
Before & After Your Hip Replacement
What to Expect
Hip replacement surgery is a major step toward getting your life back — and iovera° helps make the recovery smoother. A brief, in-office cryotherapy treatment before your surgery reduces pain signals around the hip, so you need fewer pain medications and can get moving again sooner.
- Total Hip Replacement
- Hip Revision Surgery
- Hip Resurfacing
- Chronic Hip Pain (non-surgical)
The iovera° treatment is performed 1–3 days before your hip replacement. It's an outpatient procedure — no hospital stay required — and takes about 30–45 minutes.
With pain signals already reduced, you need less anesthesia and experience a smoother recovery room experience.
Less pain means you can start walking and doing physical therapy sooner, which is key to a successful hip replacement outcome.
Many patients are able to go home the same day or the next day. You'll have fewer opioid prescriptions to manage during recovery.
Shoulder Pain Relief
Before & After Rotator Cuff or Shoulder Replacement
What to Expect
Shoulder surgery — whether it's a rotator cuff repair or a shoulder replacement — can be painful during recovery. iovera° cryotherapy calms the sensory nerves around your shoulder before surgery, reducing pain and helping you get more out of physical therapy during the weeks that matter most.
- Rotator Cuff Repair
- Total Shoulder Replacement
- Reverse Shoulder Replacement
- Shoulder Labrum Repair
- Chronic Shoulder Pain
The iovera° treatment is applied to the nerves around your shoulder 1–3 days before your procedure. It takes about 25–35 minutes in the office.
Pre-treated patients report less pain waking up from surgery and a more comfortable recovery room experience.
Reduced pain in the first weeks after surgery means you can participate more fully in physical therapy — which directly impacts how well your shoulder heals.
Improved function scores at 6 and 12 weeks show that patients who received iovera° recover faster and with less reliance on pain medication.
Bursitis & Hip Pain Relief
Non-Surgical Treatment for Outer Hip Pain
What to Expect
If you have persistent pain on the outside of your hip — often called trochanteric bursitis or greater trochanteric pain syndrome — iovera° offers a drug-free, non-surgical option that lasts far longer than a steroid injection. A single in-office treatment can provide up to 90 days of relief.
- Greater Trochanteric Pain Syndrome
- Trochanteric Bursitis
- Iliotibial Band Syndrome
- Chronic Outer Hip Pain
- Failed Steroid Injection
Your provider will review your symptoms and confirm that iovera° is appropriate for your type of hip pain. Most patients with outer hip pain are good candidates.
The iovera° procedure takes about 20–30 minutes. You remain awake and comfortable throughout. There's no incision and no recovery room time needed.
Most patients notice pain relief within 24–48 hours. You can return to normal activities right away.
Relief typically lasts up to 90 days. As the nerves naturally regenerate, the treatment can be repeated if needed.
Want the Full Protocol Packet?
Nerve maps, landmark guides, patient education materials, and billing codes — all included.
Common Clinical Questions
Answers to the most common questions from surgical directors, orthopedic surgeons, and hospital administrators evaluating cryoneurolysis.
Ready to Add These Protocols
to Your Service Line?
Request the full protocol packet — including nerve maps, landmark guides, and patient education materials.